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An oral formulation of semaglutide lowered the risk major adverse cardiovascular events by 14% in four years, with no change in safety profile compared to placebo, according to the SOUL study. #ACC25
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View of Series: Cardiovascular outcome trials for diabetes drugs Semaglutide and SUSTAIN-6
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The PIONEER program tested oral semaglutide — the first GLP-1 receptor agonist available as a pill rather than injection. Across multiple PIONEER trials in T2DM, oral semaglutide produced HbA1c and weight reductions
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Efficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population with type 2 diabetes uncontrolled with metformin: PIONEER 12, a double-blind, Phase IIIa, randomised trial | Diabetologia
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Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, phase 3a trial
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Semaglutide (SUSTAIN and PIONEER) reduces cardiovascular events in type 2 diabetes across varying cardiovascular risk - Husain - 2020 - Diabetes, Obesity and Metabolism
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