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surmount-1 tirzepatide obesity nejm 2022 weight loss percent SURMOUNT-1 (NEJM 2022) tested tirzepatide — a dual GIP/GLP-1 receptor agonist — in 2,539 adults with obesity and achieved up to 20.9% mean weight loss at the highest dose. 57% of participants

Marsoni M251S
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Port Orchard, US
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NIce Shoes
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Very nice quality and comfort
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elizabeth a.
Carnegie, US
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Great shoe.
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Perfect fit. Stylish comfortable.
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phala riffel
Lowell, US
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Fit well Look great Get compliments all the time
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Larry
Lexington, US
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Good value for the money.
Size: 9.5 Wide, Color: Beige
Comfortable right out of the box. Great style and well made. The more you wear the softer they get but maintain their overall appearance.
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Amazon Customer
Belleville, US
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Very good quality for a reasonable price.
Size: 10, Color: Grey
Very good quality, very soft, very comfortable, look amazing, I’m very happy.
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Reviewed in the United States on May 23, 2026

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