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glp 1 api Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy: Cell Reports Medicine

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4.5 ★★★★★
Based on 2046 reviews
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Verified Purchase
Storm X
Grantham, US
★★★★★ 4
A bit heavy, so mind the sizing. Good though.
My dog is a relentless chewing Jock. He's 11 lbs of Chi X and runs and chews until he's exhausted. I got the 6" for him and it's a bit heavy. He already unraveled and ate the string tape, so I braided and knotted it. He likes it when I can get him to chase it. I'd get a 4" if I were to do it again. It's a great well made product that really let's him get a good chew on.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 22, 2026
C
Verified Purchase
CherryHill
Dallas, US
★★★★★ 5
Pup’s new favorite chew toy!
My son let one of my pups have a corn cob, which my dog enjoyed immensely. However, son got scolded as these can be very dangerous to dogs, and I disappointed my pup by taking it away. I went to Amazon to see if, by chance, a dog toy existed that was a corn cob. And there we found this- the new favorite of MANY chew toys for my medium size aggressive chewers. I bought two, one for each. They enjoyed “tug-a-war” due to the handy rope end. It squeaks. It’s strong and well made. It’s by far their favorite chew toy. I did store them in the fridge prior to giving them and pretended to eat them to make the pups think they were “real”. The package says they are dog toothbrushes, so a good benefit there as well. I’m sure we will be getting these regularly.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 2, 2025
N
Verified Purchase
nancy hahn
Boise, US
★★★★★ 1
Quality
I have a 5 lbs puppy. Within 5 minutes of giving him this toy he had pieces of the rope chewed off and in his mouth. Needless to say,into the garbage it went. Disappointed
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 24, 2026
W
Verified Purchase
Will
San Leandro, US
★★★★★ 5
Great Chew Toy for our 50 pound dog
Really great chew toy. Our 50 pound dog loves it. We play fetch with it. Very sturdy and easy to chew.
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Reviewed in the United States on March 1, 2026
J
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Judy C.
Dallas, US
★★★★★ 5
Great toy
Great for an aggressive chewer. I was pleasantly surprised this toy lasted months with my dog chewing at it. Its one of his favorite toys! It cleans easily rinsing in the sink or running it in the washing machine &holds up very well.
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Reviewed in the United States on January 24, 2026

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