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An oral formulation of semaglutide lowered the risk major adverse cardiovascular events by 14% in four years, with no change in safety profile compared to placebo, according to the SOUL study. #ACC25
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Semaglutide in Cardiometabolic Diseases: SELECTing the Target Population
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What SOUL's Post Hoc Really Tells Us
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Oral semaglutide found to lower risk of heart failure events in people with type 2 diabetes
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National Consensus on Semaglutide in Cardiology: From Clinical Evidence to Clinical Translation
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ADA 2025: Oral Semaglutide Demonstrates Cardiovascular Benefits in SOUL Trial
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At ADA 2025, the SOUL trial revealed that oral semaglutide (Rybelsus) reduced the risk of major cardiovascular events—like heart attack, stroke, and CV death—by 14% over ~4 years in type 2 diabetes
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